منابع مشابه
Erythropoietin in polycystic kidneys.
Erythropoietin (EPO) formation in kidneys of 18 patients with autosomal dominant polycystic kidney disease (ADPKD) was investigated. In 12 patients on hemodialysis and in 6 patients with preterminal renal failure serum, EPO was 29 +/- 7 and 16 +/- 1.5 mU/ml and hemoglobin concentrations were 11.0 +/- 0.6 and 12.7 +/- 1.2 g/dl, respectively. Cyst fluid from a total of 357 renal cysts was obtaine...
متن کاملGene profiling of polycystic kidneys.
BACKGROUND While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increa...
متن کاملPeritransplant management of retained native kidneys in autosomal dominant polycystic kidney disease.
As with other forms of end-stage kidney disease, transplantation is the treatment of choice for patients with autosomal dominant polycystic kidney disease (ADPKD) [1]. Transplantation is both life-extending and provides a superior quality of life for those patients who reach the need for renal replacement therapy. Most transplant centers proceed with transplantation either from a living donor o...
متن کاملClinical aspects of polycystic disease of the kidneys.
Seventy-eight patients were treated for polycystic disease of the kidneys. An analysis of the interval between the onset of symptoms and end-stage renal failure made it possible to give and accurate prognosis in individual cases. Pregnancy and urinary infection did not appear to accelerate deterioration of renal function, but Rovsing' operation precipitated renal failure in some cases. Forty-tw...
متن کاملEnhanced Autophagy in Polycystic Kidneys of AQP11 Null Mice
Aquaporin-11 (AQP11) is an intracellular water channel expressed at the endoplasmic reticulum (ER) of the proximal tubule. Its gene disruption in mice leads to intracellular vacuole formation at one week and the subsequent development of polycystic kidneys by three weeks. As the damaged proximal tubular cells with intracellular vacuoles form cysts later, we postulated that autophagy may play a ...
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ژورنال
عنوان ژورنال: Journal of Japanese Society for Dialysis Therapy
سال: 1993
ISSN: 0911-5889,1884-6211
DOI: 10.4009/jsdt1985.26.467